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MED-SuMo and MED-Hybridise: exploit all PDB macromolecule structures to design/optimize innovative leads
MEDIT
Obtaining structural information on fragment-protein target is a key factor and also a major limitation. We’ve used MED-SuMo and MED-Hybridise to query and mine the PDB seeking for similar interaction surfaces. MED-portions were used to design novel scaffolds (GPCR) and decorate a given scaffold (kinase). We have analysed the scaffolds in regard to their diversity, their presence in PubChem, PDB and other libraries.
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Phase Diagram Visualization via Continuously-Fed Crystallization: Experiments and Model
University of Minnesota
A continuously-fed crystallization chamber is manufactured to allow phase diagram visualization. This microfluidic system allows the experimenter to screen a large range of salt and protein concentrations in one experiment. This allows the experimenter to predict the protein phase diagram in a single experiment. A continuous-feed crystallization chamber has been successfully fabricated and characterized in terms of its flow profile, and has successfully predicted the phase diagram for lysozyme.
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Target Discovery World Congress, South San Francisco, CA, USA
04 August 2009 - 05 August 2009
Target Discovery World Congress will be a meeting focusing on the research looking to find new potential drugs for development. The topics will include presentations on the latest in screening platforms and new methods such as those in High Content and Label-Free Screening and will also focus on the work being done looking for new drug targets in some of the major protein families including Ion Channels, GPCRs, Protein Kinases, Nuclear Receptors and the Ubiquitin Pathway.
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Proteomics Europe, Barcelona, Spain
05 November 2009 - 06 November 2009
Welcome to the 3rd annual Proteomics Europe conference and exhibition. This year's event will take place in Barcelona, the dynamic capital city of Catalonia.
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Crystallographic Investigations on Insulin: Discovery and Development Applications
Gerd Schluckebier, Principal Scientist, Novo Nordisk A/S, speaking at Advances in Protein Crysyallography 2008
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Identification of Macromolecular Assemblies in Crystalline State
Eugene Krissinel, Researcher, European Bioinformatics Institute, speaking at Protein Crystallography 2008
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Automation, Robotics and Remote Access at the SSRL Protein Crystallography Beam Lines
Clyde Smith, Staff Scientist, Stamford University, speaking at Advances in Protein Crystallography 2008
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Multiplexed Diagnostics 2009 Market Report
Published March 2009
Multiplexed diagnostics are the long-awaited ascendance of ’omics into healthcare. The promise of multiple measurements to characterize complexity is finally being realized.
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